Prodrug strategies in anticancer chemotherapy

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August undefined, 2024

Webb10 jan. 2008 · The majority of clinically approved anticancer drugs are characterized by a narrow therapeutic window that results mainly from a high systemic toxicity of the drugs in combination with an evident lack of tumor selectivity. Besides the development of suitable galenic formulations such as liposomes or micelles, several promising prodrug … Webb1 mars 2024 · Graphical abstract. The carboxylated technology endows the paclitaxel prodrugs amphiphilic structures and superior assembling ability into nanofibers and accelerates the redox-triggered drug release of nanofibers at tumor sites, thus boosting antitumor activity. This investigation provides a facile and universal method to obtain …

Inspired heat shock protein alleviating prodrug enforces ... - Springer

WebbFurthermore, other strategies such as ADEPT (antibody-directed enzyme prodrug therapy) and the design of self-eliminating structures are introduced. Chemical realization of prodrug approaches is illustrated by drug candidates that have or may have clinical … Webbscientific article published on January 2008 chapter 1 lookism

Prodrugs as drug delivery system in oncology SpringerLink

Webb1 feb. 2008 · The prodrug strategy minimizes drug deactivation before achieving the expected molecular goal and is the starting point for research into mechanisms that … Webb1 dec. 2024 · The combinational chemo-immunotherapy as a novel treatment strategy has been widely studied and applied in clinic to enhance antitumor therapeutic efficacy and relieve side effects. WebbTargeted delivery: Many carrier-linked prodrugs have been developed over the past three decades with the goal of improving the therapeutic index of anticancer agents. In this … chapter 1 lotr

Prodrug strategies in anticancer chemotherapy. - Europe PMC

Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer …

Webb1 jan. 2008 · Prodrug strategies in anticancer chemotherapy. Kratz F, Müller IA, Ryppa C, Warnecke A Author information Affiliations All authors 1. Macromolecular Prodrugs, Tumor Biology Center, Breisacher Strasse 117, 79106 Freiburg, Germany. [email protected] Chemmedchem , 01 Jan 2008, 3 (1): 20-53 DOI: 10.1002/cmdc.200700159 … WebbEnzymes that activate prodrugs can be directed to human tumor xenografts by conjugating them to tumor-associated antibodies. After allowing for the conjugate to … chapter 1 logoWebbProdrug strategy. Chemotherapy (CT) has demonstrated important curative rates; nevertheless, the lack of specificity is still an issue as CT is responsible for side-effects … harmsen\u0027s greenhouse lamoure nd

"Webb28 jan. 2024 · Another therapeutic strategy that harnesses proteases is ... in cancer lesions, caspase 3 is not active until it is activated by various antitumor stimuli (chemotherapy, radiation, etc). Thus, the development of caspase 3-activated anticancer prodrugs may seem counterintuitive. However, this approach can be used to amplify cell ... " - Prodrug strategies in anticancer chemotherapy

Prodrug strategies in anticancer chemotherapy

β-Glucuronidase-responsive prodrugs for selective cancer chemotherapy …

Webb25 okt. 2024 · The PS prodrug forms aggregates in the systemic circulation, which helps reduce phototoxicity before reaching the tumor site. The PS prodrug increases the yield … Webb1. Introduction. Cancer is a serious threat to human health [].At present, there are many choices for cancer treatment, such as surgical resection, chemotherapy, phototherapy, immunotherapy and gene therapy [2,3,4,5,6,7].In addition to surgical resection, chemotherapy is the most commonly used remedy because of its advantages of …

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Webb15 dec. 2024 · Thus, our prodrug strategy achieves tumor-targeted pyroptosis to suppress tumor growth, thereby improving the response to anti-PD-1 therapy and extending the survival of 4T1 breast tumor-bearing mice. Consequently, this pyroptosis-based prodrug represents a novel strategy for enforcing immunogenic photodynamic therapy. WebbSalinomycin-Loaded Small-Molecule Nanoprodrugs Enhance Anticancer Activity in Hepatocellular Carcinoma . Fulltext; Metrics; Get Permission; Cite this article; Authors Wang J, Zhuo J, Tao Y, Xu S, Chen Z, Yang F, Ke Q, Xie H, Zheng S, Wang H , Xu X. Received 3 November 2024.

Webb20 okt. 2024 · The prodrug strategy to improve therapeutic selectivity relies on the biological difference between cancer and normal cells, and the therapeutic agents that target biological events which is specific for cancer cells but absent in normal cells [10]. To date, plenty of prodrug strategies for cancer cell-specific targeting have been exploited. Webb11 apr. 2024 · Paclitaxel (PTX) is a potent chemotherapeutic widely used to treat breast, lung, pancreatic, and ovarian cancers ().Considered to be one of the most successful cancer drugs of all time, PTX exerts its antitumor effects by stabilizing microtubules and promoting formation of multipolar spindles and chromosome missegregation …

WebbMethods: A dual-acting MTX, acting as both an anticancer drug and as a tumor-targeting ligand, was coupled to 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[aldehyde ... yet feasible, drug delivery strategy for targeted combination chemotherapy. Keywords: pH-sensitive prodrug, ... WebbDesigning and developing truly tumor-specific prodrugs remains a challenge in the field of cancer chemotherapy. Active targeting strategies, on the one hand, aim at exploiting …

WebbCancer continues to be responsible for the deaths of more than 9 million people worldwide each year. Current treatment options are diverse, but low success rates, particularly for those with late-stage cancers, continue to be a problem for clinicians and their patients. The effort by researchers globally to find alternative treatment options is ongoing. In the …

Webb14 apr. 2024 · Identification of Hypoxia-Targeting Drugs in the Tumor Microenvironment and Prodrug Strategies for Targeting Tumor ... 17.2.1 Organic Molecules as Bio-Reductive Hypoxia-Selective Anticancer Prodrugs. ... Smyth JF, Tattersall MHN (1980) Mechanism of action of anti-cancer drugs. In: Basic principles of cancer chemotherapy, vol 1, ... chapter 1 loftusWebbProgrammable prodrug micelle with size-shrinkage and charge-reversal for chemotherapy-improved IDO immunotherapy IDO blockade-based immunotherapy has been impeded by the activation of antitumor immune response and low delivery efficiency of immunotherapeutic, resulting from natural biological barriers and immune resistance. harms gastro gmbhWebbProdrugs are inactive compounds, which are metabolized in the body, either chemically or enzymatically, in a controlled or predictable manner, to the active parent drug. This … chapter 1 loomingsWebb8 apr. 2008 · The prodrug approach in oncology is of particular interest owing to the narrow therapeutic window of antineoplastic agents available. harms furnitureWebbTargeted prodrugs have also been explored in oncology in order to minimize side effects and improve the tolerability of chemotherapy [Citation 3]. Prodrugs are also used to increase the duration of action of medicines, ... Romidepsin is a novel anticancer agent. ... Prodrug strategy/gain Indication/use; 2008 [Citation 5] Toviaz: Fesoterodine ... harm server shopWebb8 apr. 2008 · Synthesis of prodrugs, via a glucuronidation reaction has been studied for the developpement of more selective drugs, specially for selective delivery of systemically administrated... chapter 1 lotf analysisWebbför 2 dagar sedan · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. … harms farms mchenry