WebThe Lewis X structure in its sialylated form is of special interest because this structure, when present on leukocytes, is the ligand for the cell adhesion molecules E-Selectin (the endothelial-leuko- cyte adhesion molecule [ELAM-1]) and P-Selectin (GMP140/ PADGEM/CD62), involved ... WebFeb 3, 2006 · Lewis (Le)-associated antigens are carbohydrates that are related biochemically to the ABO blood ... type 1 H, Le a, Le b, Le x, Le y and sialylated Le a (CA19-9), was evaluated immunohistochemically in 233 gastric biopsy specimens obtained at routine gastroscopy. Expression was also investigated in gastric tissues showing chronic ...
Sialyl-Lewis X - Wikipedia
WebSialylated Lewis carbohydrate structures on the surface of leukocytes normally bind to selectins signaling injured tissue sites, ... (di)-Lewis x/a GSL . Recently, another lectin of the HOP family, called LabA, was identified, targeting LacdiNAc (GalNAcβ1–4GlcNAc) residues. WebIn addition, terminal sialic acid was identified as the glycan potentially utilized by both CuV and TuV for cellular entry, with TuV showing additional recognition of poly-sialic acid and sialylated Lewis X (sLeXLeXLeX) motifs reported to be upregulated in neurotropic and cancer cells, respectively. driving with a migraine
Monoclonal Antibody Targeting Sialyl-di-Lewis a –Containing ...
WebAntigen Background. CA19-9 is an epitope on the sialylated Lewis a carbohydrate structure. Sialylated Lewis a plays a role in cell adhesion by acting as a functional ligand for the … WebA sialylated version of Lewis X antigen expressed on cell surfaces. It is a ligand for SELECTINS. Entry Term(s) 5-Acetylneuraminyl-(2-3)-Galactosyl-(1-4)-(Fucopyranosyl-(1-3)) … WebJul 24, 2024 · In breast cancer, expression of TACA such as sialyl-Lewis(x) or sialyl-Tn is usually associated with a poor prognosis and a decreased overall survival of patients. … driving with alzheimer\u0027s disease